5-MTHF Active Methylfolate

Thorne 5-MTHF provides methylfolate — the biologically active, already-methylated form of folate that cells use directly without conversion. Up to 40% of the population carries MTHFR gene variants reducing the efficiency of converting synthetic folic acid to active methylfolate by 30–70%. For these individuals, supplementing 5-MTHF bypasses this metabolic bottleneck entirely, ensuring adequate methylation support for DNA synthesis, neural tube integrity, cardiovascular health through homocysteine management, and neurotransmitter production. Gluten, dairy, and soy-free. Third-party certified. 60-serving supply.

• Directly usable by all cells—no MTHFR conversion needed for those with genetic variants
• Supports DNA synthesis, fetal development, and neural tube integrity
• Helps maintain healthy homocysteine levels for cardiovascular and cognitive health
• Promotes neurotransmitter production for mood and mental clarity
• Gluten, dairy, and soy-free with third-party certification

• Folate (as 5-Methyltetrahydrofolate, Metafolin®) — 1,000mcg DFE
• Microcrystalline Cellulose, Hypromellose (capsule)

At Hewyn, our product selection is guided by a commitment to quality and impact. We collaborate with a trusted network of health professionals who shortlist the latest and most effective items in the wellness space. Each product’s ingredients are rigorously reviewed, ensuring they’re backed by research and offer real health benefits. This process guarantees that every product on Hewyn meets our high standards, delivering only the best for your well-being.